Volume 16, Issue 1 (Jan-Feb 2022)
mljgoums 2022, 16(1): 9-12 |
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1- Department of Pharmacology, Yenepoya Medical College, Mangalore, India
2- Department of Pharmacology, Subbaiah Institute of Medical Sciences, Mangalore, India
3- Department of Pharmacology- Subbaiah Institute of Medical Sciences, Mangalore, India
4- Department of Biochemistry, Yenepoya Medical College, Mangalore, India , mahalaxmi.petimani@gmail.com
2- Department of Pharmacology, Subbaiah Institute of Medical Sciences, Mangalore, India
3- Department of Pharmacology- Subbaiah Institute of Medical Sciences, Mangalore, India
4- Department of Biochemistry, Yenepoya Medical College, Mangalore, India , mahalaxmi.petimani@gmail.com
Abstract: (2349 Views)
Background and objectives: Coronavirus disease 2019 (COVID-19) has been reported to be more severe and highly fatal in patients with co-morbidities. Thyroid dysfunction leads to multisystem derangements, as thyroid hormones have major role in the development and functioning of all the human cells. The present study evaluated the variation in the clinical and biochemical parameters of COVID-19 patients with preexisting hypothyroidism.
Methods: This retrospective cohort study was carried out on eight COVID-19 patients with hypothyroidism who were admitted to a tertiary care hospital in Mangalore, India. Various clinical and biochemical parameters of the patients were recorded.
Results: Out of eight patients, three were men and five were women. With respect to other co-morbidities, six patients had associated type-2 diabetes mellitus and the remaining two patients had no other co-morbidities apart from hypothyroidism. Regarding the severity of COVID-19, one patient had mild symptoms, two had moderate symptoms, and the remaining five patients had severe COVID-19 symptoms. Most biochemical and hematological parameters in all patients were deranged from normal values. Moreover, only 25% of the patients recovered from the disease.
Conclusion: Most COVID-19 patients with hypothyroidism had low oxygen saturation and high level of inflammatory markers. In addition, the risk of mortality in COVID-19 patients with hypothyroidism and type 2 diabetes mellitus was higher compared to patients with hypothyroidism alone. It is recommended to closely monitor COVID-19 patients with hypothyroidism and limit the use of steroids during the course of treatment.
Conclusion: Most COVID-19 patients with hypothyroidism had low oxygen saturation and high level of inflammatory markers. In addition, the risk of mortality in COVID-19 patients with hypothyroidism and type 2 diabetes mellitus was higher compared to patients with hypothyroidism alone. It is recommended to closely monitor COVID-19 patients with hypothyroidism and limit the use of steroids during the course of treatment.
Research Article: Research Article |
Subject:
Biochemistry
Received: 2021/10/11 | Accepted: 2021/12/13 | Published: 2021/12/29 | ePublished: 2021/12/29
Received: 2021/10/11 | Accepted: 2021/12/13 | Published: 2021/12/29 | ePublished: 2021/12/29
References
1. Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LFP. The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol. 2020; 20(6): 363-374. [View at Publisher] [DOI:10.1038/s41577-020-0311-8] [PubMed] [Google Scholar]
2. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395(10223): 497-506. [View at Publisher] [DOI:10.1016/S0140-6736(20)30183-5] [PubMed] [Google Scholar]
3. Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, Villamizar-Peña R, Holguin-Rivera Y, Escalera-Antezana JP, et al.. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis. 2020; 34: 101623. [View at Publisher] [DOI:10.1016/j.tmaid.2020.101623] [PubMed] [Google Scholar]
4. Tsivgoulis G, Fragkou PC, Karofylakis E, Paneta M, Papathanasiou K, Palaiodimou L, et al. Hypothyroidism is associated with prolonged COVID-19-induced anosmia: a case-control study. J Neurol Neurosurg Psychiatry. 2021; jnnp-2021-326587. [View at Publisher] [DOI:10.1136/jnnp-2021-326587] [PubMed] [Google Scholar]
5. Gokhale CN, Chavhan SS, Adsul BB, Kumbhar MA, Kinge KV, Dhikale PT, et al. COVID-19 patients with hypothyroidism: a retrospective cohort study from a dedicated COVID hospital of Mumbai, India. Int J Community Med Public Health. 2021; 8(4): 1752-6. [View at Publisher] [DOI:10.18203/2394-6040.ijcmph20211228]
6. Giovanella L, Ruggeri RM, Ovčariček PP, Campenni A, Treglia G, Deandreis D. Prevalence of thyroid dysfunction in patients with COVID-19: a systematic review. Clin Transl Imaging. 2021; 11:1-8. [View at Publisher] [DOI:10.1007/s40336-021-00419-y] [PubMed] [Google Scholar]
7. Lisco G, De Tullio A, Jirillo E, Giagulli VA, De Pergola G, Guastamacchia E, et al. Thyroid and COVID-19: a review on pathophysiological, clinical and organizational aspects. J Endocrinol Invest. 2021; 44(9): 1801-1814. [View at Publisher] [DOI:10.1007/s40618-021-01554-z] [PubMed] [Google Scholar]
8. World Health Organization. Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: interim guidance, 28 January 2020. World Health Organization. 2020. [View at Publisher]
9. Hariyanto TI, Kurniawan A. Thyroid disease is associated with severe coronavirus disease 2019 (COVID-19) infection. Diabetes Metab Syndr. 2020;14(5):1429-1430. [DOI:10.1016/j.dsx.2020.07.044] [PubMed] [Google Scholar]
10. Georges JL, Cochet H, Roger G, Ben Jemaa H, Soltani J, Azowa JB, et al. Association of hypertension and antihypertensive agents and the severity of COVID-19 pneumonia. A monocentric French prospective study. Ann Cardiol Angeiol (Paris). 2020; 69(5): 247-254. [DOI:10.1016/j.ancard.2020.09.030] [PubMed] [Google Scholar]
11. Van Gerwen M, Alsen M, Little C, Barlow J, Naymagon L, Tremblay D, et al. Outcomes of Patients With Hypothyroidism and COVID-19: A Retrospective Cohort Study. Front Endocrinol (Lausanne). 2020; 11: 565. [DOI:10.3389/fendo.2020.00565] [PubMed] [Google Scholar]
12. Duntas LH, Jonklaas J. COVID-19 and Thyroid Diseases: A Bidirectional Impact. J Endocr Soc. 2021;5(8):bvab076. [doi: 10.1210/jendso/bvab076] [PMID: 34189381] [PMCID: PMC8135350]. [View at Publisher] [DOI:10.1210/jendso/bvab076] [PubMed] [Google Scholar]
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