Volume 14, Issue 5 (Sep-Oct 2020)                   mljgoums 2020, 14(5): 25-29 | Back to browse issues page

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Shamoushaki T, Fozouni L. Fluconazole and Ibuprofen Combination: A Potential Treatment for Mucosal Candidiasis. mljgoums 2020; 14 (5) :25-29
URL: http://mlj.goums.ac.ir/article-1-1257-en.html
Fluconazole and Ibuprofen Combination: A Potential Treatment for Mucosal Candidiasis
Tahere Shamoushaki1 , Leila Fozouni 2
1- Department of Biology, Gorgan Branch, Islamic Azad University, Gorgan, Iran
2- Department of Biology, Gorgan Branch, Islamic Azad University, Gorgan, Iran , lili_kia@yahoo.com
Abstract:   (5301 Views)
Background and objectives: The incidence of drug-resistant candidiasis has increased dramatically. This study aimed to evaluate antifungal effects of fluconazole alone and in combination with ibuprofen on isolates from patients with mucosal candidiasis.
      Methods: Candida species isolates from 142 patients with suspected mucosal (oral and vaginal) candidiasis were identified by culture on CHROMagar Candida medium and carbohydrate assimilation test using the API 20CAUX kit. Minimum inhibitory concentration (MIC) of fluconazole alone and in combination with ibuprofen was determined by the broth microdilution method.
      Results: Among isolates, 43.7% were identified as Candida species (Candida albicans, Candida glabrata, Candidia parapsilosis, Candida tropicalis, Candida guilliermondii and Candida kefyr). The highest rate of fluconazole resistance was observed among C. albicans (50%) isolates. MIC90 of ibuprofen-fluconazole combination against C. albicans isolates was 32 μg/mL, which was 8-fold less than that of fluconazole alone (MIC90=256 μg/mL) (P<0.01). Moreover, the MIC90 of fluconazole-ibuprofen combination against C. parapsilosis isolates was 4-fold less than that of fluconazole alone.
      Conclusion: Our results revealed partial fluconazole resistance among Candida isolates from patients with mucosal candidiasis. However, the resistance rate decreased 2.5 fold following treatment with the ibuprofen-fluconazole combination. Therefore, it is recommended to further investigate the therapeutic potential of this drug combination for treatment of fungal infections, such as candidiasis.
Keywords: Candida, Fluconazole, Ibuprofen, Antifungal effect
Full-Text [PDF 719 kb]   (1178 Downloads)    
Research Article: Original Paper | Subject: Microbiology
Received: 2019/10/14 | Accepted: 2020/05/3 | Published: 2020/08/24 | ePublished: 2020/08/24
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