en بیوشیمی Biochemistry تحقيقي Original Paper <div><span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> Although the anti-diabetic effects of various Ficus species have been investigated in animal models, research on the blood glucose-lowering potentials of Ficus lacor Buch Ham bark remains sparse. This study evaluated the blood glucose-lowering potentials of an aqueous extract derived from Ficus labor bark in a diabetic rabbit model.<br> <b>Methods:</b> Diabetes was induced in rabbits through intravenous administration of alloxan monohydrate (120 mg/kg). 36 rabbits were divided into six groups, each consisting of six animals. Control groups included a non-diabetic control (Distilled water) and a diabetic control (Distilled water). Two experimental groups received Ficus lacor extract at doses of 100 mg/kg (Low-dose) and 200 mg/kg (High-dose) orally for six weeks. Metformin was used as an active control. A non-diabetic group (Extract control) was also administered Ficus lacor extract at 200 mg/kg. Fasting blood sugar (FBS) and post-prandial blood sugar (PP2BS) levels were measured weekly over the 6 weeks. The percentage reduction in blood glucose levels was calculated and compared for each group.<br> <b>Results:</b> The administration of both low-dose and high-dose Ficus lacor extracts resulted in significant reductions in FBS and PP2BS levels in diabetic rabbits. After six weeks, the low-dose extract group exhibited an average reduction of 38.3% in FBS and 40.5% in PP2BS, whereas the high-dose extract group showed average reductions of 35.3% in FBS and 36.3% in PP2BS.<br> <b>Conclusion</b>: The aqueous extract of Ficus lacor bark demonstrates substantial glucose-lowering activity, indicating its potential utility as a therapeutic agent in diabetes management.</span></span></div> Alloxan, Diabetes mellitus, Ficus, Hyperglycemia, Pre-Clinical 1 4 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1508-1&slc_lang=en&sid=1 Piyushkumar Mansinh Pargi drpiyushpargi@gmail.com 100319475328460028895 100319475328460028895 Yes Department of Pharmacology, GMERS Medical College, Godhra, Gujarat, India-389001 Manish Barvaliya drmanishbarvaliya@gmail.com 100319475328460028896 100319475328460028896 No Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, India-364001 Bhargav Purohit drbhargavpurohit@gmail.com 100319475328460028897 100319475328460028897 No Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, India-364001