en آسيب شناسي Pathology تحقيقي Original Paper <span style="font-size:12px;"><span style="font-family:Times New Roman;"><span style="line-height:200%"><b><span style="line-height:200%">Background:</span></b><span style="line-height:200%"> A higher occurrence of raised homocysteine levels has been reported in individuals with type 2 diabetes (T2D), particularly those with macroangiopathy and nephropathy. Given that hyperhomocysteinemia is a risk factor for T2D, mitigating this condition could potentially benefit T2D patients. This study aimed to investigate the influence of homocysteine on T2D and cardiovascular disease (CVD), as well as the factors that modify homocysteine levels.</span></span><br> <span style="line-height:200%"><b><span style="line-height:200%">Methods:</span></b><span style="line-height:200%"> This cross sectional, observational study was conducted on 122 individuals in a tertiary care center in Western India. Data related to anthropometry, demography, and biochemistry were gathered following established standards. Statistical analysis was performed using Chi-square test. A P-value of <0.05 was considered statistically significant.</span></span><br> <span style="line-height:200%"><b><span style="line-height:200%">Results: </span></b><span style="line-height:200%">The findings indicated a significantly larger percentage of hyperhomocysteinemia in males, smokers, and individuals with elevated fasting blood sugar and HbA1c levels. The proportion of subjects with high homocysteine levels was notably greater in those with high total cholesterol and triglyceride levels. A significant correlation was observed between increased serum homocysteine levels and decreased serum folic acid and vitamin B12 levels in patients with ischemic heart disease.</span></span><br> <span style="line-height:200%"><b><span style="line-height:200%">Conclusion:</span></b><span style="line-height:200%"> Elevated homocysteine levels are observed in smokers and diabetic patients, potentially leading to CVD. Furthermore, this study found a correlation between an increase in serum homocysteine levels and a decrease in serum folic acid and vitamin B12 levels in patients with ischemic heart disease.</span></span></span></span><br> &nbsp; Diabetes Mellitus, Homocysteine, Body mass index 29 31 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1307-1&slc_lang=en&sid=1 Misha Antani 100319475328460027185 100319475328460027185 No Department of Pathology, Smt Kashibai Navale Medical College, Pune, India Anjali Goyal anjali@knee.in 100319475328460027186 100319475328460027186 Yes Department of Pathology, Smt NHL Municipal Medical College, Ahmedabad, India Jalashree Rana 100319475328460027187 100319475328460027187 No Department of Pathology, GMERS Medical College, Palanpur, India