Medical Laboratory Journal
Medical Laboratory Journal
mljgoums
Medical Sciences
http://mlj.goums.ac.ir
1
admin
2538-4449
10.52547/mlj
en
jalali
1389
1
1
gregorian
2010
4
1
4
1
online
1
fulltext
fa
بافتمعده در افراد سیگاری و غیرسیگاری با علائم سوء هاضمه DNA میزان آسیباکسیداتیو به
Severity of Oxidative DNA Damage in Gastric Tissue of Smoker and Non-smoker Patients
Spring summer 2010, Vol.4, No.1 /74 Medical Laboratory Journal Severity of Oxidative DNA Damage in Gastric Tissue of Smoker and Non-smoker Patients with Dyspepsia Abstract Background and Objectives: Cigarette smoking is associated with an increase in risk of peptic ulcer and Gastro-Intestinal cancer. Toxic materials in smoke and tar have a significant role in production of carcinogenic complexes, injury to DNA and cellular proliferation in gastric cancer. The study was designed to compare the rate of injury to DNA in gastric tissue of smoker and non-smoker patients with active peptic ulcer. Material and Methods: In this Case-Control study, the case group composed of 43 smoker patients aged 45.30±13.16 with active peptic ulcer (14 female & 29 male) referred to gastroenterology clinic. The first control group consisted of 43 non-smokers without peptic ulcer (13 female & 30 male) with mean age of 42.67±16.04, and the second control group included 43 smokers without peptic ulcer (16 female & 27 male) with mean age of 44.58±12.07, and the third ones had 43 non-smoker patients with active peptic ulcer (20 female & 23 male) with mean age of 45.37±13.39. The rate of gastric mucosa DNA damage in the four groups was measured by calorimetrically method. Results: The DNA damage in gastric mucosa of smoker patients with active peptic ulcer(28.05±5.54 AP/100000bp) is higher than those of the three control groups (p<0.0001 in all case). Conclusion: Results of this study approve the direct relation between increase in DNA damage and toxic complexes existing in smoke and tar of cigarette. Key Words:Cigarette Smoking, DNA Damage, Active Peptic Ulcer Dolatkhah H Research Center of Gastroenterology and Hepatology, Tabriz University of Medical Sciences Somi MH Research Center of Gastroenterology and Hepatology, Tabriz University of Medical Sciences Fattahi E Research Center of Gastroenterology and Hepatology, Tabriz University of Medical Sciences Estakhri R Research Center of Gastroenterology and Hepatology, Tabriz University of Medical Sciences Dolatkhah N Talegani Hospital, Tabriz University of Medical Sciences Mirza-Aghazadeh A Dept. of Basic Sciences, Paramedical Faculty , Tabriz University of Medical Sciences Nourazarian,M Clinical Laboratory of Emam Reza Hospital, Tabriz University of Medical Sciences Pourasghari B Clinical Laboratory of Emam Reza Hospital,Tabriz University of Medical Sciences Corresponding: Dolatkhah, H E-mail: dolatkhahh@gmail.com
0
0
http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-1&slc_lang=fa&sid=1
H
Dolatkhah
همایون
دولتخواه
dolatkhahh@gmail.com
100319475328460013305
100319475328460013305
Yes
Research Center of Gastroenterology and
مرکز تحقیقات بیماری های گوارش و کبد، دانشگاه علوم پزشکی تبریز
MH
Somi
محمدحسن
صومی
100319475328460013306
100319475328460013306
No
علوم پزشکی تبریز
R
Estakhri
رسول
استخری
100319475328460013307
100319475328460013307
No
علوم پزشکی تبریز
N
Dolatkhah
ندا
دولتخواه
100319475328460013308
100319475328460013308
No
مرکز آموزشی درمانی طالقانی، دانشگاه علوم پزشکی تبریز
A
Mirza-Aghazadeh
احمد
میرزاآقازاده
100319475328460013309
100319475328460013309
No
گروه علوم پایه، دانشکده پیراپزشکی، دانشگاه علوم پزشکی تبریز
M
Nourazarian
منوچهر
نورآذریان
100319475328460013310
100319475328460013310
No
آزمایشگاههای بالینی، مرکز آموزشی، تحقیقاتی و درمانی امام رضا(ع) تبریز
B
Pourasghari
بهروز
پوراصغری
100319475328460013311
100319475328460013311
No
آزمایشگاههای بالینی، مرکز آموزشی، تحقیقاتی و درمانی امام رضا(ع) تبریز
E
Fattahi
ابراهیم
فتاحی
100319475328460013312
100319475328460013312
No
علوم پزشکی تبریز