Medical Laboratory Journal
Medical Laboratory Journal
mljgoums
Medical Sciences
http://mlj.goums.ac.ir
1
admin
2538-4449
10.52547/mlj
en
jalali
1398
10
1
gregorian
2020
1
1
14
1
online
1
fulltext
en
The Effect of Gallic Acid Supplement and Resistance Exercise on the Bio-markers of Liver in Intoxicated Male Rats of Anabolic Steroid
فیزیولوژی ورزشی
Sport Physiology
تحقيقي
Original Paper
<div><strong>Abstract</strong><br>
<strong> Background and Objectives:</strong> Liver is one of the vital organs of the human body. Antioxidants have been shown to play important roles in reducing liver injuries. The aim of this study was to examine the effects of gallic acid supplementation and resistance exercise on liver damage biomarkers in male rats intoxicated by steroid anabolic.<br>
<strong> Materials and Methods:</strong> Forty-two male Wistar rats were randomly divided into six equal groups: control, sham, steroid anabolic (5 mg/kg), steroid anabolic (5 mg/kg) + gallic acid supplementation (50 mg/kg), steroid anabolic (5 mg/kg) + resistance exercise, and steroid anabolic (5 mg/kg) + gallic acid supplementation (50 mg/kg) + resistance exercise. Except for control and sham groups, all groups received (injection) steroid anabolic at a dose of 5 mg / kg body weight once a week. The resistance exercise protocol was comprised of three weekly exercise sessions by 5 rep/3 set of climbing ladder for eight weeks. Data were analyzed via ANOVA and Tukey's post hoc test at a significance level of P<0.05.<br>
<strong> Results:</strong> The hepatic enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase) and bilirubin (total and direct), "In the gallic acid supplementation group (P<0.01, p<0.01, p<0.01, p<0.02, and p<0.05, respectively), resistance training group (p<0.02, p<0.01, p<0.01, p<0.01, and p<0.05, respectively), and the gallic acid supplementation group with resistance exercise (P<0.02, p<0.01, p<0.01, p<0.01, and p<0.01, respectively)" were significantly reduced compared to the anabolic steroid group.<br>
<strong> Conclusions:</strong> Gallic acid supplementation and resistance exercise significantly reduce liver damage biomarkers. However, the simultaneous use of resistance exercise and gallic acid supplementation has no increasing effects on these biomarkers.<br>
<strong>Keywords: </strong><a href="https://www.ncbi.nlm.nih.gov/mesh/68045930">Anabolic Agents</a>, gallic acid, Resistance Training.</div>
Anabolic Agents, gallic acid, Resistance Training.
44
49
http://mlj.goums.ac.ir/browse.php?a_code=A-10-773-1&slc_lang=en&sid=1
Kazem
Ranjbar
kazem.ranjbar@gmail.com
100319475328460021545
100319475328460021545
No
Department of Physical Education and Sport Sciences, Islamic Azad University, Tehran Branch, Tehran, Iran
Hassan
Matin Homaie
hasanmatinhomaee@yahoo.com
100319475328460021546
100319475328460021546
Yes
Department of Physical Education and Sport Sciences, Islamic Azad University, Tehran Branch, Tehran, Iran
Mohammad Ali
Azarbayjani
ali.azarbayjani@gmail.com
100319475328460021547
100319475328460021547
No
Department of Physical Education and Sport Sciences, Islamic Azad University, Tehran Branch, Tehran, Iran
Maghsoud
Piri
m.peeri@gmail.com
100319475328460021548
100319475328460021548
No
Department of Physical Education and Sport Sciences, Islamic Azad University, Tehran Branch, Tehran, Iran