Medical Laboratory Journal
Medical Laboratory Journal
mljgoums
Medical Sciences
http://mlj.goums.ac.ir
1
admin
2538-4449
10.52547/mlj
en
jalali
1398
8
1
gregorian
2019
11
1
13
6
online
1
fulltext
en
Disseminated and Hyperinfection Fatal Strongyloidiasis in Two Patients on Immunosuppressive Therapy: A Case Report
انگل شناسی
Parasitology
گزارش مورد
Case Report
<div><strong>ABSTRACT</strong><br>
<strong> Background and Objective:</strong><em> Strongyloides</em> infection is usually asymptomatic in healthy individuals; however, immunocompromised patients are subject to potential hyperinfection involvement. Hereby, we report disseminated and hyperinfection strongyloidiasis in two immunosuppressed patients from north of Iran, an endemic region for <em>Strongyloides stercoralis</em>.<br>
<strong>Case description: </strong>After assessment of clinical symptoms, disseminated strongyloidiasis was identified in the first case with pemphigus vulgaris by the presence of abundant larvae in direct stool smears and gastric biopsy. The second patient had metastatic carcinoma and was hospitalized with complicated symptoms. The infection was diagnosed by detection of numerous first-stage larvae in wet mount stool smears and agar plate analysis. Despite antiparasitic treatment, both patients died during the hospitalization.<br>
<strong> </strong><strong>Conclusion:</strong> Delayed diagnosis of active strongyloidiasis in immunosuppressed patients can lead to hyperinfection syndrome. Thus, screening for <em>S. stercoralis</em> infection in these patients is recommended in endemic regions to reduce mortalities.<br>
<strong> </strong><strong>Keywords:</strong> <em>Strongyloides stercoralis,</em> Disseminated strongyloidiasis, Hyperinfection.</div>
Strongyloides stercoralis, Disseminated strongyloidiasis, Hyperinfection
51
54
http://mlj.goums.ac.ir/browse.php?a_code=A-10-648-2&slc_lang=en&sid=1
AhmadReza
Meamar
meamar.ar@iums.ac.ir
100319475328460016636
100319475328460016636
No
Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Nahid
jalallou
nahidjalallou@yahoo.com
100319475328460016637
100319475328460016637
Yes
Department of Medical Laboratory Science, AJA University of Medical Sciences, Tehran, Iran
Leila
Masoori
leilamasoori@gmail.com
100319475328460016638
100319475328460016638
No
Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences
Maryam
Alipour
alipour,m@iums.ac.ir
100319475328460016639
100319475328460016639
No
Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences