Medical Laboratory Journal
Medical Laboratory Journal
mljgoums
Medical Sciences
http://mlj.goums.ac.ir
1
admin
2538-4449
10.52547/mlj
en
jalali
1397
12
1
gregorian
2019
3
1
13
2
online
1
fulltext
en
Positive Effects of Spray-Dried Streptococcus thermophilus on Healing of Second-Degree Burn Wounds in Wistar Rats
ميکروب شناسي
Microbiology
تحقيقي
Original Paper
<div><strong>ABSTRACT</strong><br>
<strong> Background and Objectives:</strong> Current medications used for the treatment of burn wounds have some side effects and disadvantages. Oral or topical administration of probiotic bacteria is thought to be useful for treatment of skin disorders. The aim of this study was to evaluate effects of spray-dried <em>Streptococcus thermophilus</em> on healing of second-degree burn wounds.<br>
<strong> Methods:</strong> After induction of second-degree burn on back of 80 male Wistar rats, the animals were randomly allocated to negative control (no treatment), first vehicle control (treatment with Eucerin), second vehicle control (treatment with skim milk) and experimental (treatment with bacterial ointment) groups. Wound healing rate (percent) and histopathological parameters of wound samples were evaluated on post-burn days 1, 3, 7 and 14.<br>
<strong> Results:</strong> On days 3 and 7, macroscopic results showed that the healing rate was significantly higher in the experimental group compared to the control groups. Histopathological analysis of wound samples showed increased fibroblastic migration, collagen formation and re-epithelialization in the wounds treated with probiotic bacteria compared with the wounds of control groups.<br>
<strong>Conclusion:</strong> Our results indicate that the topical use of spray-dried S<em>. thermophilus</em> could be useful for the treatment of burn wounds.<br>
<strong> Keywords: </strong><em>Streptococcus thermophilus</em>; Probiotics; Burns; Wound Healing; Rats.</div>
Streptococcus thermophilus, Probiotics, Burns, Wound Healing, Rats.
23
29
http://mlj.goums.ac.ir/browse.php?a_code=A-10-634-1&slc_lang=en&sid=1
Amir Abbas
Barzegari
Barzegaridoctora@gmail.com
100319475328460016370
100319475328460016370
No
Department of Biology, Faculty of Basic Science, University of Maragheh
Masood
Hashemzaei
masoud.hashemzahi@gmail.com
100319475328460016371
100319475328460016371
Yes
Department of Biology, Faculty of Basic Science, University of Maragheh
Ali Reza
ASlihematti
hematti@yahoo.com
100319475328460016372
100319475328460016372
No
Tabriz university of medical science