Medical Laboratory Journal
Medical Laboratory Journal
mljgoums
Medical Sciences
http://mlj.goums.ac.ir
1
admin
2538-4449
10.52547/mlj
en
jalali
1396
12
1
gregorian
2018
3
1
12
2
online
1
fulltext
fa
Effect of Eight Weeks of Cardiac Rehabilitation Training on PPAR-α Gene Expression in CABG Patients
تحقيقي
Original Paper
<div><strong>ABSTRACT</strong><span dir="RTL"></span><br>
<strong> Background and objectives:</strong> Cardiovascular disease is the leading cause of death worldwide. This study examined the effects of cardiac rehabilitation exercise on lipid profile and expression of peroxisome proliferator-activated receptor alpha (PPAR-α) gene in patients who underwent coronary artery bypass grafting.<br>
<strong> Methods:</strong> In this quasi-experimental study, after screening, patients who underwent coronary artery bypass grafting (CABG) were randomly divided into an experimental group (n=12) and a control group (n=12). After the surgery and discharge from hospital, the experimental group performed rehabilitation exercise for two months, while the control group did not perform any exercise after discharge from the hospital and the initial phase of rehabilitation. Fasting blood samples were collected before and after the last training session to evaluate biochemical variables and PPAR-α gene expression of lymphocytes. PPAR-α expression level was assessed by qRT-PCR. Statistical analysis was done in the SPSS software (version 20) using repeated measures.<br>
<strong> Results</strong>: In the follow-up after the two-month cardiac rehabilitation exercise, the PPAR-α gene was significantly overexpressed and plasma HDL levels increased significantly in the training group compared with the control group (P<0.05). Although the concentrations of LDL and triglycerides decreased in the experimental group, this reduction was not statistically significant (P>0.05).<br>
<strong> Conclusion</strong>: The results indicate that the protocols carried out in the study could be utilized for improving HDL levels and cardiovascular function in CABG patients.<br>
<strong> keywords</strong>: Cardiac Rehabilitation, Gene Expression, PPAR-α.</div>
Cardiac Rehabilitation, Gene Expression, PPAR-α.
27
31
http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-508&slc_lang=fa&sid=1
Babisan
Askari
100319475328460014217
100319475328460014217
Yes
Department of physical education & Sport Science, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran
Amir
Rashidlamir
100319475328460014218
100319475328460014218
No
Department of Exercise Physiology,Faculty of Physical Education & Sport Science, Ferdowsi University of Mashhad,Mashhad, Iran
Asra
Askari
100319475328460014219
100319475328460014219
No
Department of Physical Education & Sport Science, Gorgan Branch, Islamic Azad University, Gorgan, Iran
Masoumeh
Habibian
100319475328460014220
100319475328460014220
No
Department of physical education & Sport Science, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran
Arash
Saadatniya
100319475328460014221
100319475328460014221
No
Department of Exercise Physiology, Faculty of Physical Education & Sport Science, Shahid beheshti University, Tehran, Iran