TY - JOUR JF - mljgoums JO - mljgoums VL - 15 IS - 2 PY - 2021 Y1 - 2021/3/01 TI - Comparison of Combined and Aerobic Training on ABCG1 Lymphocyte Gene Expression in Middle-Aged Men Undergoing Coronary Artery Bypass Grafting TT - N2 - Background and objectives: Cardiovascular disease is one of the most important causes of mortality worldwide. The present study aimed to compare two different cardiac rehabilitation protocols on ATP-binding cassette sub-family G member 1 (ABCG1) lymphocyte expression and blood lipid profile in middle-aged men undergoing coronary artery bypass grafting. Methods: Forty five middle-aged men who had previously undergone coronary artery bypass surgery were randomly divided into three groups of control (C; n=15), aerobic training (AT; n=15) and combined training (CT; n=15). Blood samples were taken before the first and after the last exercise sessions. After isolation of mononuclear cells using Ficoll and mRNA purification, gene expression changes were examined by real-time PCR. Data were analyzed using one-way ANOVA and Bonferroni post-hoc tests. Results: Eight weeks of training intervention resulted in a significant increase in ABCG1 expression as well as a significant decrease in plasma levels of LDL, triglyceride and total cholesterol in both training groups. However, there was no significant difference between the AT and CT groups. In addition, high-density lipoprotein was significantly increased in the AT and CT groups. Conclusion: Both AT and CT can increase plasma LDL and increase ABCG1 expression and HDL concentrations, indicating the positive effects of both interventions on the prevention of atherosclerosis. SP - 28 EP - 34 AU - Moosavi, Rokhsareh AU - Rashidlamir, Amir AU - Khajeie, Rambod AU - Hejazi, Mahmoud AD - Islamic Azad University, Neyshabur Branch, Neyshabur, Iran KW - Coronary Artery Bypass KW - Circuit-Based Exercise KW - ABCG1 KW - Exercise UR - http://mlj.goums.ac.ir/article-1-1294-en.html DO - 10.52547/mlj.15.2.28 ER -