AU - Khoshdel Rad N, AU - Mashayekhi F, AU - Mirzajani E, TI - Concentration of soluble form of hepatocyte growth factor receptor in cerebrospinal fluid and serum of patients with bacterial and viral meningitis PT - JOURNAL ARTICLE TA - mljgoums JN - mljgoums VO - 6 VI - 1 IP - 1 4099 - http://mlj.goums.ac.ir/article-1-193-en.html 4100 - http://mlj.goums.ac.ir/article-1-193-en.pdf SO - mljgoums 1 ABĀ  - Abstract Background and objectives: C-Met is a proto-oncogene that encodes a protein known as hepatocyte growth factor receptor (HGFR). The HGF receptor possesses tyrosine -kinase activity and it is essential for embryonic development, wound healing and cancer. Many proteins are proteolytically released from the surface by a process known as ectodomain shedding. Shedding occurs under normal physiologic conditions and can be increased in certain pathologies. C-Met can be seen among many receptors for which ectodomain shedding has been shown. The aim of this study was to determine the concentration of soluble c-Met in the cerebrospinal fluid (CSF) and serum samples of patients with viral and bacterial meningitis. Material and Methods: in this study, 75 CSF and serum samples of patients with bacterial meningitis, 71 with viral meningitis and 82 normal controls were investigated. The soluble c-Met concentration was determined by enzyme linked immunosorbent assay (ELISA). Result: the amount of soluble c-met in CSF of patients with bacterial meningitis ( 83.91±5.50), viral meningitis ( 80.41±4.71) and control group ( 22.66±3.39) are compared with that in serum of patients with bacterial meningitis ( 561.58±25.87), viral meningitis ( 550.50 ±34.34) and control group ( 256.25±18.55). There is significant increase in the CSF and serum’s soluble c-Met expression in the patients with meningitis, in comparison with control group. Conclusion: The data presented here indicate that soluble c-Met is a constant component of human serum and CSF, but it can not be used for differentiating bacterial meningitis from viral meningitis. Key words: Soluble c-Met, concentration, cerebrospinal fluid, serum, meningitis CP - IRAN IN - Faculty of Sciences, University of Guilan, Rasht, Iran. LG - eng PB - mljgoums PG - 1 PT - Original Paper YR - 2012