Volume 7, Issue 4 (winter[PERSIAN] 2014)                   mljgoums 2014, 7(4): 34-40 | Back to browse issues page

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Tavilani H, Setarehbadi R, Fattahi A, Nasrollahi S, Karimi J, Shafiee G et al . The Relationship between Plasma Antioxidant Enzymes Activity and Sex Hormones during the Menstrual Cycle. mljgoums 2014; 7 (4) :34-40
URL: http://mlj.goums.ac.ir/article-1-378-en.html
1- Associated Professor of Biochemistry, Urology & Nephrology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2- PhD Student of Biochemistry, Student Research Committee, Hamadan University of Medical Sciences, Hamadan Iran
3- Assistant Professor of Gynecology, Department of Gynecology, Hamadan University of Medical Sciences, Hamadan, Iran
4- Assistant Professor of Biochemistry, Department of Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran
5- Assistant Professor of Anatomy, Department of Anatomy, Hamadan University of Medical Sciences, Hamadan Iran , : hosseinipanah@hotmail.com
Abstract:   (16769 Views)
Abstract Background and objective: There is increasing evidence for the role of oxidative stress in female reproductive tract. The purpose of this study was to determine the activity of antioxidant enzymes during menstrual cycle. In addition, the relationship between activity of antioxidant enzyme and sex hormones was evaluated. Materials and methods: In this study the activity of superoxide dismutase, glutathione peroxidase, glutathione reductase, catalase and total antioxidant capacity during the menses, follicular and luteal phases of the menstrual cycle in twenty women with regular menstrual cycle were studied. Furthermore, the correlation between activity of antioxidant enzymes and estradiol, progesterone, LH, FSH and testosterone were evaluated. Results: There was no significant difference between activity of superoxide dismutase, glutathione peroxidase, glutathione reductase, catalase and total antioxidant capacity during the menses, follicular and luteal phases of the menstrual cycle (P>0.05). We found significant correlation, in luteal phase, between superoxide dismutase and FSH (P<0.05، r=0.44) and LH P<0.05،r=0.54). Also it is observed between LH and glutathione peroxidase (P<0.05، r=0.44). Conclusion: Based on the results, there is no significant difference between antioxidant enzymes and total antioxidant capacity of plasma during menstrual cycle. In other words, physiologic system of women with regular menstrual cycle can protect body against oxidative stress and this is probably performed due to action of FSH and LH hormones. Keywords: Antioxidants Menstrual cycle Sex hormones
Research Article: Original Paper |
Received: 2013/11/9 | Accepted: 2013/11/9 | Published: 2013/11/9 | ePublished: 2013/11/9

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.