Volume 13, Issue 3 (May-Jun 2019)                   mljgoums 2019, 13(3): 6-10 | Back to browse issues page

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Ebrahimi A, Babaaie A, Boniadian M, Lotfalian S. Antibacterial and Ciprofloxacin-Potentiation Activities of Cinnamomum zeylanicum Extracts against Some Pathogenic Bacteria. mljgoums. 2019; 13 (3) :6-10
URL: http://mlj.goums.ac.ir/article-1-1198-en.html
1- Department of Pathobiology, School of Veterinary Science, Shahrekord University, Shahrekord, Iran
2- DVM Student of Pathobiology Department, Veterinary College, Shahrekord University, Iran
3- Department of Public Health, School of Veterinary Science, Shahrekord University, Shahrekord, Iran
4- Sharareh Lotfalian
Abstract:   (3989 Views)
             Background and Objectives: Efflux-based systems may play a role in resistance to fluoroquinolones in Gram-negative pathogenic bacteria. Extracts of some medicinal plants contain molecules that can act as efflux pumps inhibitors. In this study, we aimed to evaluate antibacterial activities of ethanolic and chloroform extracts of Cinnamomum zeylanicum and their possible synergistic activity with ciprofloxacin against some Gram-negative pathogenic bacteria. We also analyzed the extracts for presence of efflux pump inhibitors against the examined bacteria.
             Methods:  Powdered dried leaves and branches of C. zeylanicum were extracted with ethanol (85%) and chloroform by the maceration method. Minimum inhibitory concentrations of the extracts alone or combined with ciprofloxacin and phenylalanine-arginine β-naphthylamide (an efflux pump inhibitor) were determined against Pseudomonas aeruginosa, Acinetobacter bummani, Escherichia coli and Salmonella enteritidis using the double serial microdilution method.
             Results: The extracts of C. zeylanicum inhibited the growth of all studied bacteria. Synergistic effects were noted between the extracts and ciprofloxacin against all tested bacteria other than P. aeruginosa. Ciprofloxacin efflux pumps in E. coli, S. enteritiditis and A. baumannii were inhibited by the extracts of C. zeylanicum.
             Conclusion: The extracts of C. zeylanicum could be used as ciprofloxacin-potentiating agents against some Gram-negative pathogens.
             Keywords: Anti-bacterial agents, Cinnamomum zeylanicum, Bacterial pathogens, Efflux pumps.
Full-Text [PDF 558 kb]   (630 Downloads)    
Research Article: Original Paper | Subject: Sport Physiology
Received: 2019/03/5 | Accepted: 2019/03/5 | Published: 2019/03/5 | ePublished: 2019/03/5

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