en آسيب شناسي Pathology تحقيقي Original Paper <span style="font-size:12pt"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><b>Introduction:</b></span></span></span><br> <span style="font-size:12pt"><span style="line-height:200%"><span style="font-family:Calibri,sans-serif">A Frozen section is a rapid diagnostic procedure performed on tissues obtained intraoperatively, which helps the operating surgeon make immediate decisions during surgery, primarily to distinguish between benign and malignant neoplasms. It plays a significant role in guiding intra- and perioperative patient management and reduces the need for re-operation.</span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><b>Aims & Objectives:</b></span></span></span><br> <span style="font-size:12pt"><span style="line-height:200%"><span style="font-family:Calibri,sans-serif">The present study aims to evaluate the diagnostic accuracy, sensitivity and specificity of the frozen section.</span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><b>Materials & Methods: </b></span></span></span><br> <span style="font-size:12pt"><span style="line-height:200%"><span style="font-family:Calibri,sans-serif">&nbsp;Analysis of 49 frozen sections was conducted in the Pathology department from September 2022 to May 2024. The frozen section diagnoses were compared to those of the routine paraffin sections. The results were classified as concordant and discordant. Diagnostic accuracy, sensitivity, and specificity were calculated.</span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><b>Results:</b></span></span></span><br> <span style="font-size:12pt"><span style="line-height:200%"><span style="font-family:Calibri,sans-serif">&nbsp;Out of 49 cases, the diagnosis was concordant with routine histopathology in 47 cases, while 02 cases were discordant. The overall diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value were 95.92%, 96%, 95.43% ,96%, and 95.43%, respectively. The discordance rate was 4.08%.</span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><b>Discussion: </b></span></span></span><br> <span style="font-size:12pt"><span style="line-height:200%"><span style="font-family:Calibri,sans-serif">The overall diagnostic accuracy rate of 95.92% & discordance rate of 4.08% of present study is comparable to previous studies which range from 94 to 98% & 1.4% to 12.9% respectively. The sensitivity & specificity of frozen section diagnosis in present study are comparable with studies from other Institutes.</span></span></span><br> <span style="font-size:12pt"><span style="line-height:200%"><span style="font-family:Calibri,sans-serif"><b>Conclusion:</b></span></span></span><br> <span style="font-size:12pt"><span style="line-height:200%"><span style="font-family:Calibri,sans-serif">&nbsp;Frozen section is a reliable, accurate and rapid technique for intraoperative consultation. Several factors can affect the accuracy of Frozen Section diagnosis, including sampling error, technical error and interpretation error.</span></span></span><br> <br> &nbsp; Concordant, Discordant, Diagnostic accuracy, Frozen section 0 0 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1356-2&slc_lang=en&sid=1 Sarangi Wankhade sarangiwankhade90@gmail.com 100319475328460033188 0009-0004-9135-3924 No Senior Resident Department of Pathology ,TATA Memorial Centre, Advanced Centre For Treatment, Research And Education In Cancer ( ACTREC) Kharghar, Navi Mumbai, India Smita Bhide smitapbhide@gmail.com 100319475328460033189 100319475328460033189 Yes Professor & Head Department of Pathology, MIMER Medical College Talegaon Dabhade, Pune, India