en دیگر Others تحقيقي Original Paper <span style="font-size:11pt"><span style="line-height:115%"><span style="font-family:Arial,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Background:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""> Chemical analgesics often have limitations, including adverse effects and insufficient efficacy. Therefore, there is a pressing need to investigate novel compounds with enhanced efficacy and a more favorable side effect profile.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span style="font-family:Arial,sans-serif"><span style="font-size:12.0pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span style="font-family:Arial,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Methods:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""> This study aimed to evaluate the analgesic properties of <i>Rhaponticum repens</i> (RR) extract, a natural compound, using the formalin test in Wistar rats. Twenty-one male Wistar rats were randomly divided into three groups (n=7): group 1 received normal saline, group 2 received morphine (10 mg/kg), and group 3 received RR extract (100 mg/kg). Thirty minutes post-injection, formalin (2.5%) was injected into the hind paw of each rat to induce pain. Licking time and pain scores were recorded during both the acute and chronic phases of the test. Data were analyzed using one-way ANOVA with Prism software, with statistical significance set at P &le; 0.05.</span></span></span><span style="font-size:12.0pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span style="font-family:Arial,sans-serif"><span style="font-size:12.0pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span><br> <b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Results:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""> Results from both the acute and chronic phases demonstrated a significant reduction in licking time and pain scores in both the morphine and RR extract groups compared to the control group. Additionally, the extent of hind paw edema was significantly reduced in both the morphine and RR extract groups.</span></span></span> Formalin test, Pain, Rhaponticum repens, Morphine 0 0 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1857-1&slc_lang=en&sid=1 Mahsa Ranjbaran mahsaranjbaran9@gmail.com 100319475328460033283 100319475328460033283 No Department of Biology, Faculty of science, Bu-Ali Sina University, Hamedan, Iran Siamak Yari s.yari@basu.ac.ir 100319475328460033284 100319475328460033284 Yes Department of Biology, Faculty of science, Bu-Ali Sina University, Hamedan, Iran Roya Karamian karamian.roya@gmail.com 100319475328460033285 100319475328460033285 No Department of Biology, Faculty of science, Bu-Ali Sina University, Hamedan, Iran Anahita Saeidi saeedianna@gmail.com 100319475328460033286 100319475328460033286 No Department of Biology, Faculty of science, Bu-Ali Sina University, Hamedan, Iran