en دیگر Others Research Article Research Article <span style="font-size:11pt"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Abstract:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""> Autism is a disease that causes problems in speech, performing social skills, as well as repetitive, stereotyped movements and aimless behaviors. 15 to 30 percent of people with autism experience seizures. However, the reported rate of epilepsy in autism varies between 5 and 40%.<strong>Melissa officinalis plant</strong> is used in Iranian traditional medicine as a sedative, antipyretic, antispasmodic and anticonvulsant.In this research project, the possible effects of the extract of this plant on convulsions induced by PTZ in the autism model of male Wistar rats were investigated.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Methods:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""> Healthy male and female Wistar rats were selected for mating.Female mice received water and normal food until day 12.5 of pregnancy.Then they are divided into 4 groups. 1-control 2-autism group 3-autism group <strong>Melissa officinalis extract</strong>with a dose of 100mg/kg.4. Autism group + <strong>Melissa officinalis plant extract</strong>with a dose of 200mg/kg. Then, after 2 weeks, pentylenetetorazole was injected PTZ with a dose of 80 mg/kg to all groups of rats, and after that the animals&#39; behaviors will be examined for 60 minutes. Ricin criterion was used to evaluate seizure severity.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">The findings of the present study showed that the administration of the Melissa officinalis plant extract to male rats with autism has inhibitory effects on PTZ-induced seizures.</span></span></span></span></span></span><br> &nbsp; autism,Melissa officinalis plant, seizure, PTZ 0 0 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1822-1&slc_lang=en&sid=1 Fatemeh Piri fateme.piri7272f@gmail.com 100319475328460033331 100319475328460033331 No Golestan University of Medical Sciences Hamid Sepehri hamsep49@yahoo.com 100319475328460033332 100319475328460033332 Yes Golestan University of Medical Sciences